Oprah is ready to take a step toward the frontier of medicine…but she's a little scared of the whole needle part. Daniel was ready to ease her fears. "The needles that [Daniel] is going to use would actually fit through the hole in the needle that they use to take the blood from your arm," Dr. Oz says.

"Acupuncture treats any condition from allergies to, obviously, pain to gastrointestinal issues—a wide range of chronic diseases," Daniel says.

Oprah doesn't suffer from those particular ailments, so Daniel recommends a wellness acupuncture treatment, which will help boost Oprah's immune system. This normally requires about 10 needles, he says, and the positive effects will be felt anywhere from 20 minutes to days afterwards.

"It's really not bad," Oprah says. "It's not as bad as getting your ears pierced, I'll tell you that."